Resources

Scientific Resources

Videos, application notes, publications, and blog — the scientific credibility hub for ORYL Photonics.

Videos

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Product Overview

ORYL F1 in 60 Seconds — High-Throughput Solubility & Aggregation Profiling

ORYL F1 is a high-throughput, low-compound, plate-based solubility and aggregation profiling instrument,…

Video Thumbnail of Ultrafast Light Scattering

Technology

ORYL F1 — How Ultrafast Light Scattering Works | SHS + LLS in One Measurement

Most light-scattering workflows give you one readout. Ultrafast Light Scattering (ULS) gives…

Workflow

ORYL F1 — Workflow Demo | Plate to Report in Under One Hour

ORYL F1 is a plate-based solubility and aggregation profiling instrument powered by…

Application Notes

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Screenshot of AN-1002 - DMSO-QC - Front page

Discovery

AN-1002: DMSO Compound Library QC

Compound management teams store large libraries as nominal 10 mM DMSO stocks, but not every…

Screenshot of AN-1004 - Solubility LLS - Front page

Discovery

AN-1004: High-throughput solubility profiling for PROTACs, peptides and small molecules

Solubility remains a discovery bottleneck as hit lists expand, molecules become more complex, and early…

Calibration

AN-1001: SHS H₂O/D₂O Calibration

Second Harmonic Scattering (SHS) is a novel technique for studying mechanisms of solubility, aggregation and…

ROI Calculators

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Discovery, Method Selection

Solubility Techniques Comparison

HPLC-MS, HPLC-UV, DLS, or ORYL F1? Compare techniques head-to-head across cost, time, and sustainability using published per-plate consumption data — adjusted to your lab’s economics.

Compound Triage, Discovery

SPR ROI Calculator

How much does running SPR without solubility triage cost you per year? Eleven inputs, three strategies (pre-filter, SPR + resume, SPR + restart), your numbers.

Discovery, Solubility Screening

Solubility Cost Calculator

What does each solubility measurement actually cost? Surface instrument depreciation, FTE time, and plate-handling overhead — and find the break-even point for automation.

Publications

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Peer-Reviewed

High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Aqueous solubility is essential for drug absorption and bioavailability, but current assays face trade-offs between…

Peer-Reviewed

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

In this scientific article published in JPCB, we establish the experimental and theoretical foundation for…

Blog

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Blog

Calibrating Ultrafast Light Scattering

Last week we showed what the ORYL F1 workflow looks like. This week is the…

Blog

Why we call it F1

For analytical instruments in this AI era, the mantra is: Throughput. Throughput. Throughput. Too often,…

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Scientific Resources

Videos

ORYL F1 in 60 Seconds — High-Throughput Solubility & Aggregation Profiling

ORYL F1 — How Ultrafast Light Scattering Works | SHS + LLS in One Measurement

ORYL F1 — Workflow Demo | Plate to Report in Under One Hour

Application Notes

AN-1002: DMSO Compound Library QC

AN-1004: High-throughput solubility profiling for PROTACs, peptides and small molecules

AN-1001: SHS H₂O/D₂O Calibration

ROI Calculators

Solubility Techniques Comparison

SPR ROI Calculator

Solubility Cost Calculator

Publications

High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

Blog

Calibrating Ultrafast Light Scattering

Why we call it F1

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