Resources

Scientific Resources

Videos, application notes, publications, and blog — the scientific credibility hub for ORYL Photonics.

Videos

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ORYL F1 — Solubility & Aggregation Triage Before Biophysics | 384 Wells in ~15 Minutes

Is that hit a real binder — or an aggregation artifact? Every…

Workflow

ORYL F1 — Workflow Demo | Plate to Report in Under One Hour

ORYL F1 is a plate-based solubility and aggregation profiling instrument powered by…

Video Thumbnail of Ultrafast Light Scattering

Technology

ORYL F1 — How Ultrafast Light Scattering Works | SHS + LLS in One Measurement

Most light-scattering workflows give you one readout. Ultrafast Light Scattering (ULS) gives…

Application Notes

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Discovery

AN-1005: Pre-SPR solubility and aggregation triage of entire hit lists on ORYL F1

Surface Plasmon Resonance (SPR) campaigns depend on clean hit lists.

Screenshot of AN-1002 - DMSO-QC - Front page

Discovery

AN-1002: DMSO Compound Library QC

Compound management teams store large libraries as nominal 10 mM DMSO stocks,…

Screenshot of AN-1004 - Solubility LLS - Front page

Discovery

AN-1004: High-throughput solubility profiling for PROTACs, peptides and small molecules

Solubility remains a discovery bottleneck as hit lists expand, molecules become more…

ROI Calculators

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Discovery, Method Selection

Solubility Techniques Comparison

HPLC-MS, HPLC-UV, DLS, or ORYL F1? Compare techniques head-to-head across cost, time, and sustainability using published per-plate consumption data — adjusted to your lab’s economics.

Compound Triage, Discovery

SPR ROI Calculator

How much does running SPR without solubility triage cost you per year? Eleven inputs, three strategies (pre-filter, SPR + resume, SPR + restart), your numbers.

Discovery, Solubility Screening

Solubility Cost Calculator

What does each solubility measurement actually cost? Surface instrument depreciation, FTE time, and plate-handling overhead — and find the break-even point for automation.

Publications

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Peer-Reviewed

Combined second harmonic and linear light scattering as a tool for solubility and aggregation screening

Twelve poorly water-soluble drugs in 384-well plates: a new EJPS study shows what second harmonic and linear light scattering reveal together about precipitation and drug-rich assemblies.

Peer-Reviewed

High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Aqueous solubility is essential for drug absorption and bioavailability, but current assays face trade-offs between…

Blog

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Blog

What is the cost of measuring solubility & aggregation?

The largest carbon cost in a solubility and aggregation workflow is not the instrument or the solvent. It is the compound itself.

Blog, Discovery Workflows

Triage an entire small-molecule hit list for solubility and aggregation before SPR

Triage a hit list for solubility and aggregation before SPR: ~15 min per 384-well plate, ~2 µL/datapoint. Catch aggregators before they foul the chip.

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Scientific Resources

Videos

ORYL F1 — Solubility & Aggregation Triage Before Biophysics | 384 Wells in ~15 Minutes

ORYL F1 — Workflow Demo | Plate to Report in Under One Hour

ORYL F1 — How Ultrafast Light Scattering Works | SHS + LLS in One Measurement

Application Notes

AN-1005: Pre-SPR solubility and aggregation triage of entire hit lists on ORYL F1

AN-1002: DMSO Compound Library QC

AN-1004: High-throughput solubility profiling for PROTACs, peptides and small molecules

ROI Calculators

Solubility Techniques Comparison

SPR ROI Calculator

Solubility Cost Calculator

Publications

Combined second harmonic and linear light scattering as a tool for solubility and aggregation screening

High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Blog

What is the cost of measuring solubility & aggregation?

Triage an entire small-molecule hit list for solubility and aggregation before SPR

Need specific data for your application?

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