Let ORYL run the measurements for you. Send your samples and receive decision-ready solubility and aggregation data — without installing an instrument. Ideal for teams needing rapid results.
De-risk Solubility & Aggregation Early
Validate every compound — not just your lead
Decision-ready
PDF Report, CSV, plot
2 weeks
turnaround time
USD 30-40
per compound
Pricing
Transparent, volume-tiered pricing
All prices in USD. Standard aqueous buffer conditions (PBS pH 7.4). Each 384-well plate accommodates 16–24 compounds: 8-point serial dilution per compound at 2–3 replicates. Rush service (1-week turnaround) available at +USD 10/compound — confirm at time of order.
10 – 100 compounds
$40
per compound
Standard campaign or single project. Minimum invoice: USD 500.
Most common
101 – 500 compounds
$35
per compound
Lead optimisation series. Typical campaign range for pharma R&D teams.
500+ compounds
$30
per compound
High-throughput screening. Preferred partner rate for large-volume campaigns.
How we compare
How the F1 service compares
Quantitative solubility data. Faster turnaround. At 60–70% lower cost than HPLC.
| ORYL F1 Service | HPLC CRO | Nephelometry | |
|---|---|---|---|
| Cost / compound | USD 30–40
60–70% lower
|
~USD 100 | ~USD 15–40 |
| Turnaround Time | 2 weeks
2x–3x faster
|
4–6 weeks | 2–4 weeks |
| Data type | Quantitative SHS + LLS simultaneously |
Quantitative Gold standard |
Quantitative Sensitivity limited below ~20 µM |
| Compound required | ~2 µL of 10 mM DMSO stock | ~0.5–1 mg solid or solution | >10 µL of 10 mM DMSO stock |
Process
Three steps to decision-ready results
STEP 01
Request a quote
Fill in the form below with your compound count and solvent conditions. We respond within 3 business days with a formal quote, plate layout, and sample preparation instructions.
STEP 02
Ship your samples
Prepare 10 mM DMSO stock solutions (≥10 µL) per compound in a vial or sealed 96- or 384-well plate and ship to our facility. We perform our assay at 1% final DMSO concentration. We confirm receipt the same business day.
STEP 03
Receive your data
ORYL runs acoustic or manual dispensing, incubation, and F1 measurement. You receive a per-compound report via email or via data portal within 2 weeks of sample arrival.
Scope of service
What is — and isn’t — included
Each engagement covers measurement, dispensing, data processing, and reporting. Compound supply, shipping or return shipping, and HPLC-based thermodynamic solubility are not included.
Included
- UV-Star 384-well plate measurement
- ECHO acoustic or manual dispensing of samples
- Second harmonic scattering (SHS) + linear light scattering (LLS)
- Automated data processing and curve fitting
- Per-compound solubility report (µg/mL and µM)
- 2-week turnaround from sample receipt
- Project scientist support (protocol alignment)
Not included
- Compound synthesis
- Compound shipping to ORYL facility
- Return shipment of remaining compound
- Additional solvent conditions (quoted separately)
- Thermodynamic solubility (HPLC-based)
Deliverables
What you receive at the end of the project
Decision-ready outputs your team can act on immediately — structured for integration with your downstream workflows.
01
Per-compound solubility value
Reported in µg/mL or µM with confidence interval.
02
Concentration-response curves
SHS and LLS curves for each compound. We recommend the appropriate readout, i.e., LLS or SHS, based on the type of measurement.
03
Plate layout map and QC summary
Full traceability from compound ID to well position, with quality-control flags per plate.
04
PDF report
Structured, decision-ready format suitable for sharing with project teams and committees.
05
Raw data export
CSV available on request for integration with internal data systems.
Sample requirements
How to prepare and ship your samples
Please review before submitting. Non-compliant submissions may delay processing — reach out to us if you have questions.
01
Stock concentration
Assay runs at 1% final DMSO. For example, running a measurement with a maximum concentration of 100 µM requires a 10 mM DMSO stock (100 µM × 100). We require at least 10 µL per compound in order to perform replicate measurements.
02
Powder samples
Indicate the weight (in µg) and we can dissolve the powder stock in DMSO. For compounds that are insoluble or problematic in DMSO, please discuss with us before shipping.
03
Format
Submit stock solutions in vials or 96- or 384-well plates, sealed with aluminum foil.
04
Sample manifest
Accompany the shipment with a manifest (compound ID, MW, CAS where available) in Excel or CSV.
05
Shipping conditions
Compounds shipped at ambient temperature unless otherwise agreed.
06
Compound supply
Compounds are provided by the customer — ORYL does not source or synthesize compounds.
Also available
Compound Library Screening (DMSO)
Non-destructive YES / NO aggregation check of your 10 mM DMSO (or other stock concentration) stored in library plates. USD 500 per plate — we test, report, and ship the plates back to you.
Learn More
Want to dig into the technology?
Browse application notes, technology deep-dives, and case studies in our resource library — learn how Ultrafast Light Scattering compares to HPLC and nephelometry, and see the data behind the F1.
Get Started
How to prepare and ship your samples
Tell us your compound count and we will reply with a formal quote, plate layout, and sample preparation instructions within 1 business day.
Standard turnaround
2 weeks
Rush (+USD 10/compound)
1 week
Quote response
3 business days
Contact
✓
Request received
We will review your experiment details and reply with a formal quote within 3 business day.
Questions? services@orylphotonics.com