ORYL F1 is a high-throughput, low-compound, plate-based solubility and aggregation profiling instrument, powered by Ultrafast Light Scattering (ULS).
Traditional solubility and aggregation workflows are slow, compound-hungry, and often deliver answers too late in the pipeline to make a difference.
ORYL F1 delivers high-throughput, low-compound solubility and aggregation profiling powered by Ultrafast Light Scattering, enabling better decisions from discovery through formulation.
The ORYL F1 is the first plate-based instrument to combine second harmonic scattering (SHS) and linear light scattering (LLS) in a single, high-throughput platform. From early discovery screening to pre-formulation profiling, the ORYL F1 delivers robust and reliable measurements that match pharma R&D timelines.
Let ORYL run the measurements for you. Send your samples and evaluate ORYL F1 data before bringing the instrument in-house. Ideal for teams needing rapid results.
From hit-list screening in early discovery to formulation window mapping in pre-formulation, ORYL F1 supports the workflows that matter.
ORYL F1 combines second harmonic scattering (SHS) and linear light scattering (LLS) into a single measurement platform, offering complementary readouts that reveal molecular-level insight into solubility and aggregation behavior.
Probes molecular-level organization and early-onset aggregation events invisible to conventional light scattering methods.
Complements SHS with established scattering measurements to characterize particle size and aggregation growth with high sensitivity.
Detect subtle changes at the nanometer scale — early onset of aggregation prior to turbidity — giving teams earlier and more actionable insight.
Profile hundreds of conditions in minutes using standard 384-well plates, matching the pace of modern pharma R&D timelines.
The ORYL F1 is a high-throughput, low-compound, plate-based solubility and aggregation profiling instrument for pharma R&D, powered by Ultrafast Light Scattering (ULS).
ULS combines Second Harmonic Scattering (SHS) and Linear Light Scattering (LLS) on the same sample — complementary readouts that detect the early onset of aggregation before turbidity and define the solubility limit.
It profiles solubility and aggregation about 100x faster and with about 100x less compound than HPLC, and works above 50 mg/mL where DLS saturates. It is an alternative that runs before and alongside them, not a replacement.
See how ORYL F1 can deliver decision-ready solubility and aggregation results for your pipeline.
