Replace late surprises with early certainty

ORYL F1 is a high-throughput, low-compound, plate-based solubility and aggregation profiling instrument, powered by Ultrafast Light Scattering.

384 wells
Profiled in approximately 15 minutes
~100×
Less compound required vs HPLC-based methods
<1 hour
from measurement to decision-ready insights
Why ORYL

De-risk solubility and aggregation early

The Challenge

Late surprises derail drug development

Traditional solubility and aggregation workflows are slow, compound-hungry, and often deliver answers too late in the pipeline to make a difference.

  • Low throughput limits screening coverage
  • High compound consumption restricts early-stage testing
  • Late-stage solubility failures cause costly rework
  • Limited sensitivity misses early aggregation signals
The ORYL Solution

Decision-ready results, early and fast

ORYL F1 delivers high-throughput, low-compound solubility and aggregation profiling powered by Ultrafast Light Scattering, enabling better decisions from discovery through formulation.

  • Profile 384 wells in approximately 15 minutes
  • Use roughly 100× less compound than HPLC workflows
  • Detect nanometer-scale aggregation before visible turbidity
  • Plate-based format fits existing lab workflows
The ORYL F1

Built for modern pharma R&D

The ORYL F1 is the first plate-based instrument to combine second harmonic scattering (SHS) and linear light scattering (LLS) in a single, high-throughput platform. From early discovery screening to pre-formulation profiling, the ORYL F1 delivers robust and reliable measurements that match pharma R&D timelines.

384-well
Plate-based format
~15 min
Full plate measurement
SHS + LLS
Complementary readouts
High-sensitivity
Nanometer-scale detection
Measurement Services

Validate every compound — not just your lead

Let ORYL run the measurements for you. Send your samples and receive decision-ready solubility and aggregation data — without installing an instrument. Ideal for teams needing rapid results.

Decision-ready
PDFs, CSVs, plots output
2 weeks
turnaround time
USD 30-40
per compound
Applications

Built for new drug modalities

From hit-list screening in early discovery to formulation window mapping in pre-formulation, ORYL F1 supports the workflows that matter.

Technology

Powered by Ultrafast Light Scattering

ORYL F1 combines second harmonic scattering (SHS) and linear light scattering (LLS) into a single measurement platform, offering complementary readouts that reveal molecular-level insight into solubility and aggregation behavior.

Second Harmonic Scattering (SHS)

Probes molecular-level organization and early-onset aggregation events invisible to conventional light scattering methods.

Linear Light Scattering (LLS)

Complements SHS with established scattering measurements to characterize particle size and aggregation growth with high sensitivity.

High-Sensitivity Detection

Detect subtle changes at the nanometer scale — early onset of aggregation prior to turbidity — giving teams earlier and more actionable insight.

Plate-Based, High-Throughput

Profile hundreds of conditions in minutes using standard 384-well plates, matching the pace of modern pharma R&D timelines.

Ready to de-risk early?

See how ORYL F1 can deliver decision-ready solubility and aggregation results for your pipeline.