Blog

Read insights, updates, and perspectives on photonics, innovation, and industry trends from our team.

Blog

What is the cost of measuring solubility & aggregation?

The largest carbon cost in a solubility and aggregation workflow is not the instrument or the solvent. It is the compound itself.

Blog, Discovery Workflows

Triage an entire small-molecule hit list for solubility and aggregation before SPR

Triage a hit list for solubility and aggregation before SPR: ~15 min per 384-well plate, ~2 µL/datapoint. Catch aggregators before they foul the chip.

Blog

Put Solubility and Aggregation First

Most discovery teams validate solubility and aggregation after the biophysics screen. Moving it upstream — before SPR — gives you clean molecules, clean data, and fewer late surprises. Here is why that is now possible, and what it changes.

Blog

Fail fast, measure again: how ORYL found its visual identity

An eagle, a stubborn shade of green, and more iterations than I would like to…

Blog

Calibrating Ultrafast Light Scattering

Last week we showed what the ORYL F1 workflow looks like. This week is the…

Blog

Why we call it F1

For analytical instruments in this AI era, the mantra is: Throughput. Throughput. Throughput. Too often,…

Blog, Comparison & ROI

Why we priced our measurement service the way we did

On Nick Sleep, the ORYL F1, and the simple-things rule.

Blog, Technology

Two scattering signals. One measurement. Why that matters.

This post explains why we are positioning ORYL F1 around a category we call Ultrafast…

Blog, New Modalities

Stop inventing a new solubility workflow for every modality

Your small-molecule workflow wasn’t built for PROTACs. Your PROTAC workaround wasn’t built for peptides. And…

Blog, Company News

Why we built ORYL F1

A drug discovery pipeline funnels around 5,000 to 10,000 compounds down to ~250, down to…

Blog, Discovery Workflows

Your shortlist is ranking the wrong things first

What happens when solubility data arrives late? By the time solubility and aggregation data arrives,…

Blog, Discovery Workflows

Are you struggling to profile the solubility and aggregation of your precious APIs?

A drug must be absorbed by the body to reach its intended biological target. However,…

Blog, Technology

Second Harmonic Scattering

At ORYL Photonics, we developed a technology based on Second Harmonic Scattering (SHS). This is…

Blog, Technology

Water is not an invisible background

When investigating a biological or a drug molecule, researchers tend to focus on the molecule…

Blog, Technology

The Solvent Redistribution method

What is the Solvent Redistribution (SR) method? The solvent redistribution (SR) method is based on…

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Blog

What is the cost of measuring solubility & aggregation?

Triage an entire small-molecule hit list for solubility and aggregation before SPR

Put Solubility and Aggregation First

Fail fast, measure again: how ORYL found its visual identity

Calibrating Ultrafast Light Scattering

Why we call it F1

Why we priced our measurement service the way we did

Two scattering signals. One measurement. Why that matters.

Stop inventing a new solubility workflow for every modality

Why we built ORYL F1

Your shortlist is ranking the wrong things first

Are you struggling to profile the solubility and aggregation of your precious APIs?

Second Harmonic Scattering

Water is not an invisible background

The Solvent Redistribution method

Need specific data for your application?

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