Validate every compound — not just your lead

A contract measurement service. Ship DMSO compound stocks and receive ORYL F1 solubility and aggregation data within two weeks. Volume-tiered pricing starts at USD 1,500 flat for the 1–15 compound Starter tier; full rate card on the Measurement Services page.

Pharma, biotech, academic and AI-driven discovery teams that need ORYL F1 solubility and aggregation data without acquiring an instrument. The service makes per-compound contract pricing economically viable in a way HPLC services cannot match.

No. The Measurement Service is a complementary access mode for teams without on-premise instrumentation. All service data and protocols transfer to in-house operation without revalidation when a customer later brings the instrument in-house.

ORYL F1 achieves HPLC-level sensitivity through Ultrafast Light Scattering — Second Harmonic Scattering (SHS) and Linear Light Scattering (LLS) on the same sample. Unlike HPLC, F1 measures the physical onset of aggregation directly rather than measuring solubility via column separation. The SHS principle has been validated against HPLC shake-flask in a peer-reviewed paper in International Journal of Pharmaceutics (2025, doi.org/10.1016/j.ijpharm.2025.126200); See the high-throughput solubility measurements based on LLS that demonstrate sensitivities down to nanomolar concentration.

ORYL F1 is similar to DLS, SLS and nephelometry in that it is based on light scattering. F1 however is based Ultrafast Light Scattering that is sensitive to early onset of aggregation. Check the high-throughput solubility workflow application note that demonstrates the F1 ability to measure the solubility of small molecules, PROTACs and peptides down to nanomolar concentrations. Unlike DLS, SLS and HPLC, F1 is also the only plate-based instrument that profiles high-concentration biologics above 50 mg/mL, without dilution or path length compression.

Yes. The SHS measurement principle is supported by two peer-reviewed publications: a comparison of SHS to HPLC shake-flask in International Journal of Pharmaceutics (2025, doi.org/10.1016/j.ijpharm.2025.126200), and a solvent redistribution study in The Journal of Physical Chemistry B (2025, doi.org/10.1021/acs.jpcb.5c03073). ;

Three reasons. First, throughput: a 384-well plate runs in about 15 minutes versus an HPLC, one well at 4 minutes (384 x 4 = 1546), so per-compound instrument time drops by ~100x. Second, sensitivity: higher signal-to-noise means fewer replicates and lower sample volumes for confident results. Third, owned technology: ORYL invented and manufactures the F1 platform, so we capture cost efficiencies that resellers and HPLC CROs cannot. We can achieve 100x higher throughput at HPLC-level quality. Thus, the lower price reflects better unit economics, not lower data quality.

Yes — the published rates are the actual price, no negotiation. A 250-compound order from an academic lab and a 250-compound order from a top-10 pharma pay the same per-compound rate. No hidden setup fees inside the published tiers, no per-plate surcharges. The only variations are explicitly listed: rush turnaround (+40 percent surcharge), additional buffer conditions (quoted), and non-DMSO or powder sample preparation (quoted). Transparent pricing across sectors is a feature, not a weakness.

Standard turnaround is two weeks from receipt of samples. Rush turnaround of one week is available at a 40 percent surcharge — confirm at time of order.

Validated use-cases include small molecules, PROTACs, peptides (including constrained peptides and macrocycles), oligonucleotides and siRNA at high concentration. Most molecular constructs measurable by light scattering can be profiled, even cloudy formulations.

Kinetic solubility at 1 percent final DMSO concentration in PBS pH 7.4, with 8-point serial dilution and 2 to 3 replicates per compound. Each 384-well plate accommodates 16 to 24 compounds. This matches early-discovery decision-making for hit triage, compound QC, and lead-optimisation series. Direct measurement by dissolving powder is doable but not high-throughput — ORYL F1 is a measurement platform.

Not as a default service. ORYL F1 is optimised for kinetic measurement at scale. For thermodynamic solubility you may want to combine F1 (rapid triage) with HPLC-based shake-flask for late-stage candidates. See the Limitations section below.

Yes, but it is a different workflow. Indicate the weight (mg) and we can dissolve the stock in DMSO. For compounds insoluble or problematic in DMSO, contact us before shipping.

Yes. One condition (PBS pH 7.4) is included in standard pricing. Additional conditions — non-aqueous buffers, biorelevant media (FaSSIF, FeSSIF), or custom compositions — are quoted on request, since instrument time scales linearly with the number of conditions. Email services@orylphotonics.com with your buffer composition and we will scope it.

Light scattering measurements are largely insensitive to absorption and fluorescence properties. This is an advantage over UV-based and fluorescence-based methods, which can produce artefactual results for chromophoric or fluorophoric compounds.

10 mM DMSO stocks (at least 10 µL per compound) in vials or 96- or 384-well plates, sealed with aluminium foil, shipped at ambient temperature with a compound manifest (CSV or Excel containing compound ID, MW, CAS where available). Email services@orylphotonics.com for the detailed shipping guide.

Mutual confidentiality covered by ORYL Measurement Service Terms & Conditions, accepted at point of order. Separate NDA available on request for customers requiring it.

A structured PDF report plus CSV raw data on request, with concentration-response plots, delivered by email or secure data portal. CSV exports are structured for direct import into common ELN and LIMS systems. For custom data formats or API delivery, contact services@orylphotonics.com.

Yes. ORYL has a standard MSA template available for direct customers. For pharma, we can also enter into your company’s preferred MSA framework. Contact services@orylphotonics.com.

Standard Net 30 for established customers. The Starter tier (USD 1,500 flat) can be paid by card at the time of order. Smaller first-time orders may require prepayment or PO confirmation. Multi-project framework agreements available for ongoing engagements.

Yes — common for pharma R&D groups running parallel projects. Volume tier pricing can be applied across aggregated PO commitments. Contact services@orylphotonics.com to scope a framework arrangement.

The ORYL F1 Measurement Service is designed for research-stage decision-making — hit triage, lead optimisation, compound QC — and is not currently offered under GLP or GMP. For GLP-grade work, contact us to discuss scope.

Yes — the Starter tier (USD 1,500 flat, up to 15 compounds) is designed exactly for this. Many customers start with a pilot on known reference compounds plus a few internal challenges to benchmark F1 against their existing data before scaling up.

On request we can include one or two industry-standard reference compounds (for example a known soluble and a known aggregator) in your plate at no additional cost, so you can validate F1 against your existing knowledge before scaling up.

Every report includes QC flags per plate and per compound. If a measurement fails QC, we re-run at no charge. If you have questions about specific data points, our project scientist will walk you through them.