We will accelerate your crystallization process by failing fast! With the ORYL screener, we provide immediate and actionable feedback to guide the choice of crystallization conditions. Instead of waiting for micron-sized crystals to appear, we monitor the onset of nano-crystal formation and follow the dynamics of nano-crystal growth. Crystalize your proteins now and save time and money.

Oryl Screener

We will improve your crystallization process

Protein crystallization is used to investigate the structure and function of proteins (or other biomolecules). It is used to understand how proteins function in order to develop better drugs and vaccines and to cure diseases. Crystallization is a repetitive and time consuming process (more art than science) and is a major bottleneck in the early phases of drug discovery. With the ORYL Screener we can help you solve the structure of your proteins and accelerate your crystallization process:

  • Find crystals that lead to structure. By automatically monitoring the growth of crystals at each well condition, we can help eliminate null conditions as well as identify conditions that lead to precipitate, micro crystals, or macro crystals.
Oryl Screener Find Crystals

The beautiful crystal in (A) didn’t attract, the ugly looking crystal in (C) diffracted the best.
Image courtesy of FEBS PRESS – Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination.

  • Find crystals with the right size. Depending on your experiments, we can help you grow macro-crystals (>1 µm) for single crystal X-ray diffraction or nano-crystals (< 1 µm) for micro electron diffraction (MicroED) or for X-ray free electron lasers (XFELs).
  • Particle size measurement. Aside from finding the crystal, the ORYL screener can perform routine particle size measurement of your drops and characterize the homogeneity of your nano-crystals.
  • Solubility limit of small chemical compounds. As an added bonus, the ORYL screener can determine the solubility limit of small chemical compounds in a 96 well plate format. Now you can be assured of the quality of your chemical libraries.
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Efficiency and Throughput

Accelerate your crystallization process. Enhance your efficiency and throughput and focus on your biological question.

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Immediate Feedback

Guide the choice of crystallization conditions through immediate and trustworthy feedback.

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Save Time and Money

Crystallize you proteins now and save time and money.

How It Works

How it works

Our technology is based on second harmonic generation (SHG), a second-order nonlinear optical process where two input photons of the same frequency are spatially and temporally overlapped to generate an output photon of twice the frequency. It is a nonlinear optical effect that is inherently sensitive to orientational order. This means that groups of molecules that are oriented in the same direction (e.g. crystals) will generate a strong SHG response while groups of molecules that are randomly oriented (e.g. precipitate) will generate a weak SHG response. For more information on the theory of SHG, visit Method – LBP on EPFL website.

The Oryl Screener will help you find micro or macro crystals depending on your experiment needs.

Step 1: Automated Screening

Automated Screening

Systematic detection of crystalline conditions:

  • Differentiate crystalline structures
    from amorphous precipitates
  • Monitor nano-crystal growth

Step 2: Analysis


Automated analysis of chemical phase space

  • Systematically identify candidate conditions

Step 3: Obtain the right crystal size

Macro Crystals

Imaging: MACRO-crystals, >1 µm

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Light scattering: MICRO-crystals, <1 µm